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08/06/2017 Recherche

Programme de la Journée MIChem 2017

Le 15 juin 2017 se tient la journée bilan annuelle du Labex. Amphi 15 de 9h à 17h30.

 

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Matinée

9h00-9h40 : Présentation de Corinne Aubert et Matthieu Sollogoub

9h40-10h00 : Activation et contrôle électrochimique de la liaison halogène non-covalente

Claire Fave,  Bernd Schöllhorn  (UMR 7591 Laboratoire d’Electrochimie Moléculaire)

10h00-10h20 : Double core hole states in molecules: half thesis (co-shared with University of Gothenburg)

Marc Simon (LCPMR), Dimitris Koulentianos (University of Gothenburg-UPMC/LCPMR)

States of atoms and molecules where two inner shell electrons have been simultaneously removed are referred as double core hole (DCH) states and are of great scientific interest. The formation of DCH states in the HCl molecule has been investigated by means of high resolution electron spectroscopy. The observed spectral features which are related with the formation of different types of DCH states have been identified and assigned by using a sophisticated fit model and performing quantum chemical calculations. 

10h20-10h40 : Design of polymer-based theranostic agents for imaging and targeted delivery of antitumor metallodrugs - Metnanomed

Malcolm Jeremy Zimbron, Michèle Salmain, Nicolas Illy, Philippe Guégan (UPMC, IPCM équipes Chembio et chimie des polymères)

Des co-polymères dibloc amphiphiles comprenant un fragment PEG hydrophile et un fragment PEEGE hydrophobe ont été préparés par polymérisation anionique. En milieu aqueux, ces polymères forment des micelles d’environ 100 nm de diamètre capables d’encapsuler la curcumine ainsi qu’une métallodrogue à base d’iridium. En parallèle, il a été synthétisé des dyades fluorescentes Iridium-BODIPY. L’internalisation de ces dyades dans des cellules cancéreuses a été étudiée par microscopie de fluorescence.

10h40-11h10 : Pause-café, installation des posters

 

11h10-11h30 : Synthesis and catalytic applications of ferromagnetic hcp-cobalt nanoparticles

Anthony Vivien, Marc Petit (IPCM), Christophe Petit (MONARIS), Caroline Salzemann (MONARIS), Hélène Gérard (LCT).

11h30-11h50 : TSP-1 Mimetic Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and SAR Studies. (PEPTI-LIFE : 2014/2017)

Thomas Denèfle (LBM - UMR7203), Elodie Pramil (CRC - UMR1138 and LBM-UMR7203), Pascal Grondin (OncoDesign - Les Ulis), François-Xavier Ogi (NanoTemper - Munich), Olivier Lequin (LBM - UMR7203), Santos Susin (CRC - UMR1138) and Philippe Karoyan* (LBM - UMR7203) 

Thrombospondin-1 (TSP-1) is a glycoprotein considered as a key actor within the tumor microenvironment. Its binding to CD47, a cell surface receptor, triggers programmed cell death. Previous studies allowed the identification of 4N1K decapeptide derived from the TSP-1/CD47 binding epitope. Here, we demonstrate that this peptide is able to induce selective apoptosis of various cancer cell lines while sparing normal cells. A structure?activity relationship study led to the design of PKHB1 the first serum stable TSP-1 mimetic agonist peptide able to trigger selective programmed cell death (PCD) of at least lung, breast, and colorectal cancer cells. Altogether, these results will be of valuable interest for further investigation in the design of potent CD47 agonist peptides, opening new perspectives for the development of original anticancer therapies.

11h50-12h00 : Annonce de l’inauguration de la plateforme RMN de Jussieu

Claire Troufflard , Ingénieur RMN et Maldi-Tof (IPCM - UMR 8232)

 

12h00 – 14h00 : Buffet, posters et discussions

 

Après-midi

14h00-14h30 : La SATT Lutech et le transfert de technologie

Marie-Odile Lafon, SATT Lutech

14h30-14h50 : Low temperature evolution of the nuclear spin isomers of water in space and laboratory: SPACEOPARA Project

Thomas Putaud,  Xavier Michaut , Mathieu Bertin, Jean-Hugues Fillion, Darek Lis (LERMA  UMR 8112)

As part of his thesis, Thomas Putaud develops laboratory experiments to quantify the effects of nuclear spin conversion of water molecule at low temperature. The aim is to provide laboratory data for the interpretation of spectra observed by space telescopes. I will present the information that could be obtained in rare gas matrix and the knowledge of the spatial environments that we have from the models describing regions of space called the Photon-Dominated Regions.

14h50-15h10 : Interatomic Coulombic Decay in water clusters: ICD-Water

Nicolas Sisourat, Stéphane Carniato (LCPMR), Bruno Madebène (MONARIS), Selma Engin (LCPMR/MONARIS)               

Free electrons and radical cations produced by ionizing water molecules in biological organisms are responsible for most of the radiation damages. During the last decade a novel effect called Intermolecular Coulombic Decay (ICD) has been identified as a direct source of these genotoxic species (see figure). We are investigating ab initio the ICD effect in small water clusters as biochemical model systems. Our first results obtained on water dimer will be presented.

 

15h10-15h30 : Enhancing the magnetic anisotropy of maghemite nanoparticles via the surface  coordination of molecular complexes

Yoann Prado a,b , Thomas Georgelin c , Marie-Anne Arrio d , Philippe Sainctavit d , Christophe  Cartier dit Moulin a , Vincent Dupuis b , Jérôme Fresnais b , Benoit Fleury a , Laurent Lisnard a,e
(a : IPCM, Equipe ERMMES, UPMC, Paris, France ; b : PHENIX, Equipe Colloïdes Inorganiques, UPMC, Paris ; c : LRS,  UPMC, Paris ; d : IMPMC, UPMC, Paris ; e : CNRS UMR 7201, IPCM, Paris, France)

15h30-15h50 : Capturing of electrochemical transformations by in situ nanospectroscopy : Project: “Tip-Enhanced Raman Spectroscopy for the Characterization of Functionalized Surfaces”

Thomas Touzalin, Suzanne Joiret, Maisonhaute Emmanuel, Ivan T. Lucas (LISE - UMR 8235)

The emerging Tip-Enhanced Raman Spectroscopy (TERS) is a promising analytical tool for the characterization of materials at the nanoscale under the condition of their operation. We demonstrate in this work the ability for TERS to capture the electrochemical transformation of a molecular layer self-assembled on a tapered gold microelectrode. The proposed set-up and protocol opens new perspectives in the characterization and development of redox architectures for molecular devices.

 

 

 

15h50-16h20 : Pause-café, désinstallation des posters

 

16h20-16h40 : Binary Superlattices From Magnetic Nanocrystals and Polyoxometalates : FuNaPol

Romain Breitwieser1,2 , Thomas Auvray1,2 , Florence Volatron2, Caroline Salzemann1, Anh-Tu Ngo1, Pierre-Antoine Albouy3 , Anna Proust2 , and Christophe Petit1 (1 : MONARIS-UMR 8233, 2 : IPCM-UMR 8232, 3 : LPS-UMR 8502)

The successful coassembly of maghemite nanocrystals and giant polyoxometalates (POMs) such as {Mo132} is presented. Both electronic microscopy and small angles X-ray scattering data reveal a AB-type structure and an enhanced structuration of the magnetic nanocrystals (MNCs) assembly with POMs in octahedral interstices. In addition, POMs of larger effective diameter can be employed as spacer blocks to tune the dipolar interactions in nanocrystal assemblies.

 

16h40-17h00 : Improving density-functional theory for non-covalent interactions with application to micro-hydrated organic complexes : DFT4NCI

Cairedine Kalai, Emilie-Laure Zins1, Julien Toulouse2 et Esmaïl Alikhani1 (1 : MONARIS, UMR 8233, UPMC- CNRSLCT, 2 : UMR 7616, UPMC-CNR)

Cette thèse s'intéresse aux phénomènes de micro-hydratation de composés organiques à l'échelle moléculaire. Des méthodes basées sur une fonction d'onde sont capables de rendre compte des phénomènes de micro-hydratation avec une précision approchant la réalité expérimentale. Or, ces méthodes sont limitées par la taille du système. L'utilisation de la théorie de DFT reste indispensable à une étude de complexes hydratés.

 

 

 

Ces méthodes ne prennent pas en compte les interactions de nature dispersive. Des corrections empiriques ont été proposées récemment pour pallier ce problème. D'autres alternatives pour la prise en compte des effets de dispersion reposent sur l'emploi de méthodes hybrides fonction d'onde/DFT. Ceci peut s'effectuer en introduisant une séparation de portée dans le traitement des interactions électroniques.

17h00-17h20 : Improving density-functional theory for non-covalent interactions with application  to micro-hydrated organic complexes : DFT4NCI

Cairedine Kalai, Emilie-Laure Zins 1, Julien Toulouse 2  et Esmaïl Alikhani 1
(1 : MONARIS, UMR 8233, UPMC- CNRS, 2 : LCT, UMR 7616, UPMC-CNRS)

17h20-17h30 : Conclusions et mot de la fin