Les axes d'applications
Theme I: Chemistry for Health
Dr ANNE VESSIÈRES-JAOUEN
Concept: Theragnosis: integrated device for therapy (targeted drug delivery under stimulus) and diagnosis (molecular multi-modal imaging)
The development of a multiscale integrated chemistry opens the way to new therapeutic and diagnostic approaches. We will focus, in this project on one of the major challenges in modern medicine which is the treatment of cancer associated with the presence of metastases. The ultimate challenge, that we wish to address here, is to combine diagnosis and treatment of this phenomenon at the earliest possible stage, an ideal strategy recently coined “theragnosis” involving simultaneous targeting, carrying, imaging and delivery of new drugs.
Theme II: Chemistry and Environment
Pr FRANÇOIS ROCHET
From green synthesis to trapping and sequestration of pollutants: an integrated approach
The present thematic axis combines molecular and macromolecular chemistry on the one hand, and physical chemistry, on the other hand. It will address various studies:
- The discovery and the development of original synthetic processes fulfilling the requirements of sustainable chemistry
- The recycling of catalysts and the trapping/sequestration of unavoidable hazardous by-products (organic, metallorganic pollutants, gas)
- The in situ, real time physicochemical/structural study of catalysts and trapping materials. This question will be addressed by an intensive use of French and European large-scale facilities, like neutron and synchrotron x-ray sources.
Theme III: Interstellar and Planetary Chemistry
Pr PHILIPPE PARENT
This theme will tackle key issues in planetary and interstellar astrochemistry, addressing both gas-phase and solid-gas processes through theoretical and experimental studies:
- For gas-phase processes: the main goal will be to bring new insights in the understanding of appearance and disappearance of chemical species in the interstellar medium and the planetary atmospheres (Earth included)
- For solid-gas processes: the study will concern the role of heterogeneous chemistry involving atoms and small radicals in the formation of the key molecules in the interstellar space media and their evolution on the way to complexity
Theme IV: Nanochemistry for Energy and Information Nanotechnologies
Pr CHRISTOPHE PETIT, PROF. ANNA PROUST
This part of the project is directed towards Energy and Nanotechnologies as the main fields of application. Taking into account the properties of the individual functionalised edifices and patterned surfaces by supramolecular chemistry, 2D and 3D platforms can be elaborated. These platforms will be declined through three main targets: (i) the design of periodic magnetic architectures for information storage; (ii) organised donor-acceptor nanostructures to improve the electronic processes and the related conversion efficiency in photovoltaic devices; (iii) new materials for non-CO2 energy production and storage in specially designed 2D or 3D stable matrixes (proton or lithium conductors).
Theme V: Chemistry and Cultural Heritage
Pr LUDOVIC BELLOT-GURLET
The microstructure (metals, ceramics) or, even, nanostructure (glasses, polymers) of all materials results from their origin and/or technological history. Approaches developed through spectroscopies (Raman, infrared, X-rays) are based on sensitive probes which allow micro-analyses and non invasive investigations. Physico-chemistry should thus help the deciphering of ancient technologies and the providing of objective analysis (genuine-copy/restored-embellished discrimination or dating, weathering, diagnoses and procedures for restoration/conservation).
This will call for high performance laboratory devices, to large facilities (as synchrotron) and adapted portable instruments. Challenges offered by the chemistry of cultural heritage materials will benefit from instrument development, analytical and imaging procedures, and simulation of spectroscopic responses.